Publications

2017

Hirche C, Frenz T, Haas S, Döring M, Borst K. Tegtmeyer P, Brizic I, Jordan S, Keyser K, Chhatbar C, Pronk E, Lin S, Messerle M, Jonjic S, Falk CS, Trumpp A, Essers MAG, Kalinke U. (2017). Systemic Virus Infections differentially modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo. Cell Reports, In Press

Velten L, Haas SF, Raffel S, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Hofmann W-K, Ho AD, Huber W, Trumpp A#, Essers MAG#, Steinmetz LM#. (2017). Human haematopoietic stem cell lineage commitment is a continuous process. Nat. Cell Biol. 19: 271-281 # shared corresponding author

Garz A-K, Wolf S, Grath S, Gaidzik V, Habringer S, Vick B, Rudelius M, Ziegenhain C, Herold S, Weickert M-T, Smets M, Peschel C, Oostendorp R, Bultmann S, Jeremias I, Thiede C, Döhner K, Keller U, Götze K. Azacitidinecombined with the selective FLT3 kinase inhibitor crenolanib disrupts stromal protection and inhibits expansion of residual leukemia-initiation cells in FLT3-ITD AML with concurrent epigenetic mutations. Oncotarget 2017, October.

Schreck C*, Istvánffy R*, Ziegenhain C, Sippenauer T, Ruf F, Henkel L, Gärtner F, Vieth B, Florian C, Mende N, Taubenberger A, Prendergast A, Wagner A, Pagel C, Grziwok S, Götze K, Guck J, Dean D, Massberg S, Essers M, Waskow C, Geiger H, Schiemann M, Peschel C, Enard W, Oostendorp R. Niche WNT5A regulates the actin cytoskeleton duringregeneration of hematopoietic stem cells. JEM 2017, Jan. [http://jem.rupress.org/content/early/2016/12/20/jem.20151414]

2016

Müller TA, Grundler R, Istvanffy R, Rudelius M, Hennighausen L, Illert AL, Duyster J. Lineage specific STAT5 target gene activation in hematopoietic progenitor cells predicts the FLT3+-mediated leukemic phenotype. Leukemia. 2016 Apr 5. doi: 10.1038/leu.2016.72. [http://www.ncbi.nlm.nih.gov/pubmed/27046463]

Scognamiglio R, Cabezas-Wallscheid N, Thier MC, Altamura S, Reyes A, Prendergast ÁM, Baumgärtner D, Carnevalli LS, Atzberger A, Haas S, von Paleske L, Boroviak T, Wörsdörfer P, Essers MA, Kloz U, Eisenman RN, Edenhofer F, Bertone P, Huber W, van der Hoeven F, Smith A, and Trumpp A. Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause. Cell. 2016 Feb 11;164(4):668-80. doi: 10.1016/j.cell.2015.12.033.[http://www.cell.com/cell/fulltext/S0092-8674%2815%2901697-9]

Klein C, Zwick A, Kissel S, Forster C U, Pfeifer D, Follo M, Illert A L, Decker S, Benkler T, Pahl H, Oostendorp R, Aumann K, Duyster J, and Dierks C. Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression. J Exp Med 2016 213:273-290. Published February 1, 2016 [http://jem.rupress.org/content/213/2/273.short]

Jilg S, Reidel V, Müller-Thomas C, König J, Schauwecker J, Höckendorf U, Huberle C, Gorka O, Schmidt B, Burgkart R, Ruland J, Kolb HJ, Peschel C, Oostendorp RAJ, Götze KS, Jost PJ. Blockade of BCL-2 proteins efficiently induces apoptosis in progenitor cells of high-risk myelodysplastic syndromes patients. Leukemia. 2016 Jan;30(1):112-23. doi: 10.1038/leu.2015.179. Epub 2015 Jul 8. [http://www.ncbi.nlm.nih.gov/pubmed/26153654]

Uckelmann H, Blaszkiewicz S,* Nicolae C,* Haas S, Schnell A, Wurzer S, Wagener R, Aszodi A and Essers M. Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4. JEM. 2016 Sept 19 [http://jem.rupress.org/content/213/10/1961.abstract]

Ruf F, Schreck C, Wagner A, Grziwok S, Pagel C, Romero S, Kieslinger M, Shimono A, Peschel C, Götze KS, Istvanffy R, Oostendorp R. Loss of Sfrp2 in the Niche Amplifies Stress-Induced Cellular Responses, and Impairs the In Vivo Regeneration of the Hematopoietic Stem Cell Pool. Stem Cells. 2016 Jun 30 [http://www.ncbi.nlm.nih.gov/pubmed/27299503]

Diesch J, Zwick A, Garz A-K, Palau A, Buschbeck M, Götze K. A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers. Clin Epigenetics. 8,71 [http://www.ncbi.nlm.nih.gov/pubmed/27330573]

Eichner R, Heider M, Fernández-Sáiz V, van Bebber F, Garz AK, Lemeer S, Rudelius M, Targosz BS, Jacobs L, Knorn AM, Slawska J, Platzbecker U, Germing U, Langer C, Knop S, Einsele H, Peschel C, Haass C, Keller U, Schmid B, Götze KS, Kuster B, Bassermann F. Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity.Nat Med. 2016 Jul;22(7):735-43. doi: 10.1038/nm.4128. Epub 2016 Jun 13. [http://www.ncbi.nlm.nih.gov/pubmed/27294876]

Rahmig S, Kronstein-Wiedemann R, Fohgrub J, Kronstein N, Nevmerzhitskaya A, Bornha ̈M, Gassmann M, Platz A, Ordemann R, Tonn T, Waskow C. Regeneration in Hematopoiesis and Animal Models in Improved Human Erythropoiesis and Platelet Formation in Humanized NSGW41 Mice. StemCell Reports 2016 [http://www.sciencedirect.com/science/article/pii/S2213671116301722]

2015

Waskow C. Maintaining What Is Already There: Strategies to Rectify HSC Transplantation Dilemmas. Cell Stem Cell. 2015 Sep 3;17(3):258-9. doi: 10.1016/j.stem.2015.08.012. [http://www.cell.com/cell-stem-cell/fulltext/S1934-5909%2815%2900367-7]

Istvánffy R, Vilne B, Schreck C, Ruf F, Pagel C, Grziwok S, Henkel L, Prazeres da Costa O, Berndt J, Stümpflen V, Götze KS, Schiemann M, Peschel C, Mewes HW, Oostendorp RAJ. Stroma-Derived Connective Tissue Growth Factor Maintains Cell Cycle Progression and Repopulation Activity of Hematopoietic Stem Cells In Vitro. Stem Cell Reports. 2015 Nov 10;5(5):702-15. doi: 10.1016/j.stemcr.2015.09.018. Epub 2015 Oct 29. [http://www.ncbi.nlm.nih.gov/pubmed/26527384]

Franke K, Vilne B, Prazeres da Costa O, Rudelius M, Peschel C, Oostendorp RAJ, Keller U. In vivo hematopoietic Myc activation directs a transcriptional signature in endothelial cells within the bone marrow microenvironment. Oncotarget. 2015 Sep 8;6(26):21827-39. [http://www.ncbi.nlm.nih.gov/pubmed/26308666]

Ruppert R, Moser M, Sperandio M, Rognoni E, Orban M, Liu WH, Schulz AS, Oostendorp RAJ, Massberg S, Fässler R. Kindlin-3-mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells. J Exp Med. 2015 Aug 24;212(9):1415-32. doi: 10.1084/jem.20150269. Epub 2015 Aug 17. [http://www.ncbi.nlm.nih.gov/pubmed/26282877]

Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast ÁM, Schnell A, Hexel K, Santarella-Mellwig R, Blaszkiewicz S, Kuck A, Geiger H, Milsom MD, Steinmetz LM, Schroeder T, Trumpp A, Krijgsveld J, Essers MA. Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors. Cell Stem Cell. 2015;17: 422-34. doi: 10.1016/j.stem.2015.07.007. Epub 2015 Aug 20 [http://www.ncbi.nlm.nih.gov/pubmed/26299573]

Mende N, Kuchen EE, Lesche M, Grinenko T, Kokkaliaris KD, Hanenberg H, Lindemann D, Dahl A, Platz A, Höfer T, Calegari F, Waskow C. CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo. J Exp Med. 2015 Jul 27;212(8):1171-83. doi: 10.1084/jem.20150308. Epub 2015 Jul 6. [http://www.ncbi.nlm.nih.gov/pubmed/26150472]

V Tomiatti, R Istvánffy, E Pietschmann, S Kratzat, A Hoellein, L Quintanilla-Fend, N von Bubnoff, C Peschel, RAJ Oostendorp, U Keller. Cks1 is a critical regulator of hematopoietic stem cell quiescence and cycling, operating upstream of Cdk inhibitors. Oncogene. 2015; 34(33):4347-57. doi: 10.1038/onc.2014.364. Epub 2014 Nov 24 [http://www.ncbi.nlm.nih.gov/pubmed/25417705]

Cosgun KN, Rahmig S, Mende N, Reinke S, Hauber I, Schäfer C, Petzold A, Weisbach H, Heidkamp G, Purbojo A, Cesnjevar R, Platz A, Bornhäuser M, Schmitz M, Dudziak D, Hauber J, Kirberg J, Waskow C. Kit Regulates HSC Engraftment across the Human-Mouse Species Barrier. Cell Stem Cell. 2014 Aug 7 [http://www.cell.com/cell-stem-cell/abstract/S1934-5909(14)00249-5]

2014

Jin S, Kim J, Willert T, Klein-Rodewald T, Garcia-Dominguez M, Mosqueira M, Fink R, Esposito I, Hofbauer LC, Charnay P, Kieslinger M. Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1. Nat Commun. 2014 May 2;5:3793. doi: 10.1038/ncomms4793. [http://www.ncbi.nlm.nih.gov/pubmed/24786561]

Ehninger A, Boch T, Medyouf H, Müdder K, Orend G, Trumpp A. Loss of SPARC protects hematopoietic stem cells from chemotherapy toxicity by accelerating their return to quiescence. Blood. 2014; 123: 4054-63. [http://www.ncbi.nlm.nih.gov/pubmed/24833352]

Cosgun KN, Rahmig S, Mende N, Reinke S, Hauber I, Schäfer C, Petzold A, Weisbach H, Heidkamp G, Purbojo A, Cesnjevar R, Platz A, Bornhäuser M, Schmitz M, Dudziak D, Hauber J, Kirberg J, Waskow C. Kit regulates HSC engraftment across the human-mouse species barrier. Cell Stem Cell. 2014; 15: 227-38. [http://www.ncbi.nlm.nih.gov/pubmed/25017720]

Grinenko T, Arndt K, Portz M, Mende N, Günther M, Cosgun KN, Alexopoulou D, Lakshmanaperumal N, Henry I, Dahl A, Waskow C. Clonal expansion capacity defines two consecutive developmental stages of long-term hematopoietic stem cells. J Exp Med. 2014; 211: 209-15.[http://www.ncbi.nlm.nih.gov/pubmed/24446490]

Schreck C, Bock F, Grziwok S, Oostendorp RAJ, Istvánffy R. Regulation of hematopoiesis by activators and inhibitors of Wnt signaling from the niche. Ann N Y Acad Sci. 2014; 1310: 32-43.[http://www.ncbi.nlm.nih.gov/pubmed/24611828]